Quotes from Abstract TEM analysis of CD3/CD28-stimulated T cells suggested a significant increase in the levels of apoptotic and necrotic cell death in T cells from ME/CFS patients (over 2-fold). Stimulated T Cells of ME/CFS patients also had higher numbers of swollen mitochondria. We also found a large increase in […]
Author: John Duncan
New study finds microclots in ME*; a potential treatment target?
Dr Jaeger therefore decided that this could be adapted to remove microclots from the circulation of Long Covid patients, by a sophisticated process of filtration. The technique involves continuous removal of blood from one arm vein whence it is filtered, before being returned to the opposite arm.
Peroxisomes, Mitochondria, and Fibrinoid Microclots: Two New Preprints.
Perhaps the most perplexing aspect of myalgic encephalomyelitis is not any feature of the disease which, after all, has been subject to limited investigation, but the deafening non-response of the world’s governments, the American and British governments especially, which is a response against human decency. Nevertheless, in spite of this, […]
Myalgic Encephalomyelitis – Could there be a wrench in the mitochondrial motor?
If there is a problem in the mitochondria (and ATP-synthase especially), given their centrality to the cell’s energy production, (and thus to virtually all the functions of life) this would also have the effect of simplifying things–since it is likely whatever is impairing the mitochondria is either a direct cause or proximate to the pathomechanism of myalgic encephalomyelitis…
Timely Interview of John Chia by Amy Proal!
Over the last two decades Dr. John Chia, an infectious disease specialist, has painstakingly built an evidence base for enteroviral causation in myalgic encephalomyelitis (ME).
August and September Research Review – Part 1
(Part 2 will be shorter) A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. 1 Lead Authors: Fredrik and August Hoel. I believe this new paper from Norway (including the well-known Fluge and Mella as coauthors) is a seminal contribution to the understanding of the metabolic derangement […]
A Short, Simple Hypothesis
Dumping Recyclables After wrestling with this problem for many years, the only explanation I can come up with is that the cumulative sum of blood vessel diameter is reduced. The pipes are smaller than they should be. David Bell, MD. Former Chairman of the CFSCC and chief investigator of the […]
Begin at the beginning…
Meno: And how will you enquire, Socrates, into that which you do not know? What will you put forth as the subject of enquiry? And if you find what you want, how will you ever know that this is the thing which you did not know? Plato, Meno. Hi Everyone. For a long […]